A Cell-Phone-Based Acoustofluidic Platform for Quantitative Point-of-Care Testing.

ABSTRACT: Acoustofluidic methods, with advantages including simplicity of device design, biocompatible manipulation, and low power consumption, have been touted as promising tools for point-of-care (POC) testing. Here, we report a cell-phone-based acoustofluidic platform that uses acoustic radiation forces to enrich nanoscale analytes and red and green fluorescence nanoparticles (SiO₂@R and G@SiO₂) as probes for POC visual testing. Thus, the color signals from the fluorescent probes are enhanced, and colorimetric sensitivity is significantly improved. As a POC demonstration, the acoustofluidic platform is used to detect hemoglobin (Hb) from human blood, resulting in a rapid and straightforward measurement of normal blood Hb levels. Combining an acoustofluidic-based nanoparticle

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7335639 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature