Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study.

ABSTRACT: Background:The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of nonhospitalized individuals with influenza-like illness (ILI). Methods:Peripheral blood lymphocytes were collected from 27 patients with ILI and 27 with SARI, at time of enrollment and then 2 weeks later. Innate and adaptive cellular immune responses were assessed by flow cytometry, and serum cytokine levels were assessed by a bead-based assay. Results:During the acute phase, SARI was associated with significantly reduced numbers of circulating myeloid dendritic cells, CD192+ monocytes, and influenza virus-specific CD8+ and CD4+ T cells as compared to I

SUBMITTER: Wong SS 

PROVIDER: S-EPMC7335675 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature