Optimal Adjuvant Treatment Approach After Upfront Resection of Pancreatic Cancer: Revisiting the Role of Radiation Based on Pathologic Features.

ABSTRACT:

Objective

To identify the survival benefit of different adjuvant approaches and factors influencing their efficacy after upfront resection of pancreatic ductal adenocarcinoma (PDAC).

Summary background data

The optimal adjuvant approach for PDAC remains controversial.

Methods

Patients from the National Cancer Database who underwent upfront PDAC resection from 2010 to 2014 were analyzed to determine clinical outcomes of different adjuvant treatment approaches, stratified according to pathologic characteristics. Factors associated with overall survival were identified with multivariable logistic regression and Cox proportional hazards were used to compare overall survival of different treatment approaches in the whole cohort, and propensity score matched groups.

Resu

SUBMITTER: Moaven O 

PROVIDER: S-EPMC7335684 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature