Diabetes and Hepatocellular Carcinoma: Incidence Trends and Impact of Liver Disease Etiology.

ABSTRACT:

Background/aims

Hepatocellular carcinoma (HCC) remains the leading cause of cancer-related death among patients with type 2 diabetes mellitus (T2DM). We aimed to assess the independent role of T2DM on HCC risk among patients with different liver disease etiologies.

Methods

We analyzed the United Network for Organ Sharing database of all adults registered for liver transplantation (LT) between February 27, 2002 and December 31, 2017. For initial analyses, patients were divided into four groups: nonalcoholic steatohepatitis (NASH) and all other etiologies with or without T2DM. For additional analyses, we divided them based on underlying etiology. Logistic regression was used to evaluate the impact of T2DM with NASH and other etiologies on HCC risk.

Results

Overall, 24,1

SUBMITTER: Doycheva I 

PROVIDER: S-EPMC7335702 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature