HIV-Resistant and HIV-Specific CAR-Modified CD4⁺ T Cells Mitigate HIV Disease Progression and Confer CD4⁺ T Cell Help In Vivo.

ABSTRACT: HIV infection preferentially depletes HIV-specific CD4⁺ T cells, thereby impairing antiviral immunity. In this study, we explored the therapeutic utility of adoptively transferred CD4⁺ T cells expressing an HIV-specific chimeric antigen receptor (CAR₄) to restore CD4⁺ T cell function to the global HIV-specific immune response. We demonstrated that CAR₄ T cells directly suppressed in vitro HIV replication and eliminated virus-infected cells. Notably, CAR₄ T cells containing intracellular domains (ICDs) derived from the CD28 receptor family (ICOS and CD28) exhibited superior effector functions compared to the tumor necrosis factor receptor (TNFR) family ICDs (CD27, OX40, and 4-1BB). However, despite demonstrating limited in vi

SUBMITTER: Maldini CR 

PROVIDER: S-EPMC7335752 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature