The O₂-independent pathway of ubiquinone biosynthesis is essential for denitrification in Pseudomonas aeruginosa.

ABSTRACT: Many proteobacteria, such as Escherichia coli, contain two main types of quinones: benzoquinones, represented by ubiquinone (UQ) and naphthoquinones, such as menaquinone (MK), and dimethyl-menaquinone (DMK). MK and DMK function predominantly in anaerobic respiratory chains, whereas UQ is the major electron carrier in the reduction of dioxygen. However, this division of labor is probably not very strict. Indeed, a pathway that produces UQ under anaerobic conditions in an UbiU-, UbiV-, and UbiT-dependent manner has been discovered recently in E. coli Its physiological relevance is not yet understood, because MK and DMK are also present in E. coli Here, we established that UQ₉ is the major quinone of Pseudomonas aeruginosa and is required for growth unde

SUBMITTER: Vo CD 

PROVIDER: S-EPMC7335794 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature