Subjective cognitive and non-cognitive complaints and brain MRI biomarkers in the MEMENTO cohort.

ABSTRACT:

Introduction

Subjective cognitive complaints may be a signature of preclinical stage Alzheimer's disease. However, the link between subjective cognitive and non-cognitive complaints and brain alterations remains unclear.

Methods

The relationship between cognitive and non-cognitive complaints and brain biomarkers, measured by structural magnetic resonance imaging, was investigated in 2056 participants of the MEMENTO cohort of outpatients, who were dementia-free at baseline. We assessed whether the cognitive status at inclusion or the presence of the apolipoprotein E gene variant (APOE) ε4 could modulate the association between the intensity of complaints and brain lesions.

Results

Smaller hippocampal volume was associated with higher memory complaints and discom

SUBMITTER: Dauphinot V 

PROVIDER: S-EPMC7335902 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature