Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome.

ABSTRACT:

Introduction

Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease (AD) and its associated dementia, warranting the development of strategies to improve early detection when prevention is possible.

Methods

Using a broad battery of neuropsychological assessments, informant interviews, and clinical record review, we evaluated the psychometrics of measures in a large sample of 561 adults with DS. We tracked longitudinal stability or decline in functioning in a subsample of 269 participants over a period of 3 years, all initially without indications of clinically significant aging-related decline.

Results

Results identified an array of objective measures that demonstrated sensitivity in distinguishing individuals with incident "mild cognitive

SUBMITTER: Krinsky-McHale SJ 

PROVIDER: S-EPMC7335903 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature