Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments.

ABSTRACT: Experimental approaches such as fiber diffraction and cryo-electron microscopy reconstruction have defined regulatory positions of tropomyosin on actin but have not, as yet, succeeded at determining key atomic-level contacts between these proteins or fully substantiated the dynamics of their interactions at a structural level. To overcome this deficiency, we have previously employed computational approaches to deduce global dynamics of thin filament components by energy landscape determination and molecular dynamics simulations. Still, these approaches remain computationally challenging for any complex and large macromolecular assembly like the thin filament. For example, tropomyosin cable wrapping around actin of thin filaments features both head-to-tail polymeric interactions and local t

SUBMITTER: Pavadai E 

PROVIDER: S-EPMC7335911 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature