Cerebellar-cortical dysconnectivity in resting-state associated with sensorimotor tasks in schizophrenia.

ABSTRACT: Abnormalities of cerebellar function have been implicated in the pathophysiology of schizophrenia. Since the cerebellum has afferent and efferent projections to diverse brain regions, abnormalities in cerebellar lobules could affect functional connectivity with multiple functional systems in the brain. Prior studies, however, have not examined the relationship of individual cerebellar lobules with motor and nonmotor resting-state functional networks. We evaluated these relationships using resting-state fMRI in 30 patients with a schizophrenia-spectrum disorder and 37 healthy comparison participants. For connectivity analyses, the cerebellum was parcellated into 18 lobular and vermal regions, and functional connectivity of each lobule to 10 major functional networks in the cerebrum was eval

SUBMITTER: Kim DJ 

PROVIDER: S-EPMC7336143 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature