IPNHOT: a knowledge-based approach for identifying protein-nucleic acid interaction hot spots.

ABSTRACT:

Background

The interaction between proteins and nucleic acids plays pivotal roles in various biological processes such as transcription, translation, and gene regulation. Hot spots are a small set of residues that contribute most to the binding affinity of a protein-nucleic acid interaction. Compared to the extensive studies of the hot spots on protein-protein interfaces, the hot spot residues within protein-nucleic acids interfaces remain less well-studied, in part because mutagenesis data for protein-nucleic acids interaction are not as abundant as that for protein-protein interactions.

Results

In this study, we built a new computational model, iPNHOT, to effectively predict hot spot residues on protein-nucleic acids interfaces. One training data set and an independent tes

SUBMITTER: Zhu X 

PROVIDER: S-EPMC7336410 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature