A novel signature based on microvascular invasion predicts the recurrence of HCC.

ABSTRACT:

Background and objectives

In hepatocellular carcinoma (HCC) patients, microvascular invasion (MVI) is associated with worse outcomes regardless of treatment. No single reliable preoperative factor exists to predict MVI. The aim of the work described here was to develop a new MVI- based mRNA biomarker to differentiate between high and low risk patients.

Methods

Using The Cancer Genome Atlas (TCGA) database, we collected data from 315 HCC patients, including mRNA expression and complete clinical data. We generated a seven-mRNA signature to predict patient outcomes. The mRNA signature was validated using the GSE36376 cohort. Finally, we tested the formula in our own 53 HCC patients using qPCR for the seven mRNAs and analyzing the computed tomography (CT) features.

Results

SUBMITTER: Du B 

PROVIDER: S-EPMC7336478 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature