A methylation-based mRNA signature predicts survival in patients with gastric cancer.

ABSTRACT:

Background

Evidence suggests that altered DNA methylation plays a causative role in the occurrence, progression and prognosis of gastric cancer (GC). Thus, methylated-differentially expressed genes (MDEGs) could potentially serve as biomarkers and therapeutic targets in GC.

Methods

Four genomics profiling datasets were used to identify MDEGs. Gene Ontology enrichment and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analysis were used to explore the biological roles of MDEGs in GC. Univariate Cox and LASSO analysis were used to identify survival-related MDEGs and to construct a MDEGs-based signature. The prognostic performance was evaluated in two independent cohorts.

Results

We identified a total of 255 MDEGs, including 192 hypermethylation-low expressi

SUBMITTER: Li Y 

PROVIDER: S-EPMC7336496 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature