Immunogenicity of Inactivated Varicella Zoster Vaccine in Autologous Hematopoietic Stem Cell Transplant Recipients and Patients With Solid or Hematologic Cancer.

ABSTRACT:

Background

In phase 3 trials, inactivated varicella zoster virus (VZV) vaccine (ZV_IN) was well tolerated and efficacious against herpes zoster (HZ) in autologous hematopoietic stem cell transplant (auto-HSCT) recipients and patients with solid tumor malignancies receiving chemotherapy (STMc) but did not reduce HZ incidence in patients with hematologic malignancies (HMs). Here, we describe ZV_IN immunogenicity from these studies.

Methods

Patients were randomized to ZV_IN or placebo (4 doses). Immunogenicity was assessed by glycoprotein enzyme-linked immunosorbent assay (gpELISA) and VZV interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) assay in patients receiving all 4 doses without developing HZ at the time of blood sampling.

Results

SUBMITTER: Boeckh MJ 

PROVIDER: S-EPMC7336559 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature