Registration of phase 3 crossover trials on ClinicalTrials.gov.

ABSTRACT:

Background

In a randomized crossover trial, each participant is randomized to a sequence of treatments and treatment effect is estimated based on within-individual difference because each participant serves as his/her own control. This feature makes the design and reporting of randomized crossover trials different from that of parallel trials. Our objective was to characterize phase 3 crossover trials with results reported on ClinicalTrials.gov and identify issues and best practices for reporting.

Methods

We searched ClinicalTrials.gov for phase 3 randomized crossover trials that provided results, registered at least one primary outcome, and included at least one link to a results publication in the record by August 6, 2019. Two reviewers independently assessed the eligibili

SUBMITTER: Zeng L 

PROVIDER: S-EPMC7336618 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature