Current status of development of methylation biomarkers for in vitro diagnostic IVD applications.

ABSTRACT: A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition screening through early diagnostics to personalization of patient care and monitoring of the relapse and chronic disease. Thus disease-related methylation changes are an attractive source of the biomarkers that can have significant impact on precision medicine. However, the translation of the research findings in methylation biomarkers field to clinical practice is at the very least not satisfactory. That is mainly because the evidence generated in research studies indicating the utility of the disease-related methylation change to predict clinical outcome is in majority of the cases not

SUBMITTER: Taryma-Lesniak O 

PROVIDER: S-EPMC7336678 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature