Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database.

ABSTRACT:

Background

Ischemic cardiomyopathy (ICM) is one of the most usual causes of death worldwide. This study aimed to find the candidate gene for ICM.

Methods

We studied differentially expressed genes (DEGs) in ICM compared to healthy control. According to these DEGs, we carried out the functional annotation, protein-protein interaction (PPI) network and transcriptional regulatory network constructions. The expression of selected candidate genes were confirmed using a published dataset and Quantitative real time polymerase chain reaction (qRT-PCR).

Results

From three Gene Expression Omnibus (GEO) datasets, we acquired 1081 DEGs (578 up-regulated and 503 down-regulated genes) between ICM and healthy control. The functional annotation analysis revealed that cardiac muscle co

SUBMITTER: Dang H 

PROVIDER: S-EPMC7336680 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature