Roles of HOTAIR in lung cancer susceptibility and prognosis.

ABSTRACT:

Background

Long noncoding (lncRNA) single-nucleotide polymorphisms (SNPs) are associated with the susceptibility to the development of various malignant tumors. The aim of this study was to investigate the roles of HOX transcript antisense intergenic RNA (HOTAIR) and its SNPs in lung cancer.

Methods

Initially, the expression of HOTAIR in different tumors was investigated using the online Gene Expression Profiling Interactive Analysis (GEPIA) resource. Three SNPs (rs920778, rs1899663, and rs4759314) of HOTAIR were identified using the MassArray system. Following this, the relationship between these SNPs and susceptibility to lung cancer was investigated.

Results

Expression of HOTAIR was found to increase in a variety of cancers, including nonsmall cell lung cancer (NSC

SUBMITTER: Ren MM 

PROVIDER: S-EPMC7336741 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature