Candidate gene associations reveal sex-specific Graves' disease risk alleles among Chinese Han populations.

ABSTRACT:

Background

With several susceptibility single nucleotide polymorphisms identified by case-control association studies, Graves' disease is one of the most common forms of autoimmune thyroid disease. In this study, we aimed to determine whether any observed differences in genetic associations are influenced by sex in Chinese Han populations.

Methods

A total of 8,835 patients with Graves' disease and 9,936 sex-matched healthy controls were enrolled in the study. Confirmed by a two-staged association analysis, sex-specific analyses among 20 Graves' disease susceptibility loci were conducted.

Results

A significant sex-gene interaction was detected primarily at rs5912838 on Xq21.1 between the GPR174 and ITM2A genes, whereby male Graves' disease patients possessed a signific

SUBMITTER: Yan CY 

PROVIDER: S-EPMC7336758 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature