Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population.

ABSTRACT:

Background

ZDHHC2 is a member of the DHHC protein family, mediating palmitoylation of postsynaptic density-95 (PSD-95) and A-kinase-anchoring protein 79/150 (AKAP79/150). Genome-wide association studies (GWASs) have identified ZDHHC2 as a candidate gene for schizophrenia (SCZ). We aimed to fine-map variants of ZDHHC2 conferring risk to SCZ in the Han Chinese population.

Methods

Targeted sequencing of whole-exome sequences including untranslated regions (UTRs) along with neighboring regions in 1,827 schizophrenic patients and 1,004 normal controls of Han Chinese origin.

Results

A total of 123 variants, including five common and 118 rare variants, were identified. Among common variants, rs73198534, rs530313445, and rs74406481 were significantly associated with SCZ. Nine

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7336764 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature