C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis.

ABSTRACT:

Background

Patients critically ill with coronavirus disease-2019 (COVID-19) feature hyperinflammation, and the associated biomarkers may be beneficial for risk stratification. We aimed to investigate the association between several biomarkers, including serum C-reactive protein (CRP), procalcitonin (PCT), D-dimer, and serum ferritin, and COVID-19 severity.

Methods

We performed a comprehensive systematic literature search through electronic databases. The outcome of interest for this study was the composite poor outcome, which comprises mortality, acute respiratory distress syndrome, need for care in an intensive care unit, and severe COVID-19.

Results

A total of 5350 patients were pooled from 25 studies. Elevated CRP was associated with an increased composite poor out

SUBMITTER: Huang I 

PROVIDER: S-EPMC7336828 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature