Alcohol Cue-Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self-Administration.

ABSTRACT:

Background

Human laboratory paradigms are a pillar in medication development for alcohol use disorders (AUD). Neuroimaging paradigms, in which individuals are exposed to cues that elicit neural correlates of alcohol craving (e.g., mesocorticolimbic activation), are increasingly utilized to test the effects of AUD medications. Elucidation of the translational effects of these neuroimaging paradigms on human laboratory paradigms, such as self-administration, is warranted. The current study is a secondary analysis examining whether alcohol cue-induced activation in the ventral striatum is predictive of subsequent alcohol self-administration in the laboratory.

Methods

Non-treatment-seeking heavy drinkers of East Asian descent (n = 41) completed a randomized, placebo-controlled,

SUBMITTER: Lim AC 

PROVIDER: S-EPMC7336863 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature