Fingerprinting Orientation Distribution Functions in diffusion MRI detects smaller crossing angles.

ABSTRACT: Diffusion tractography is routinely used to study white matter architecture and brain connectivity in vivo. A key step for successful tractography of neuronal tracts is the correct identification of tract directions in each voxel. Here we propose a fingerprinting-based methodology to identify these fiber directions in Orientation Distribution Functions, dubbed ODF-Fingerprinting (ODF-FP). In ODF-FP, fiber configurations are selected based on the similarity between measured ODFs and elements in a pre-computed library. In noisy ODFs, the library matching algorithm penalizes the more complex fiber configurations. ODF simulations and analysis of bootstrapped partial and whole-brain in vivo datasets show that the ODF-FP approach improves the detection of fiber pairs with small crossing angles w

SUBMITTER: Baete SH 

PROVIDER: S-EPMC7336899 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature