Association between the number and size of intrapulmonary lymph nodes and chronic obstructive pulmonary disease severity.

ABSTRACT:

Purpose

One of the main pathophysiological mechanisms of chronic obstructive pulmonary disease is inflammation, which has been associated with lymphadenopathy. Intrapulmonary lymph nodes can be identified on CT as perifissural nodules (PFN). We investigated the association between the number and size of PFNs and measures of COPD severity.

Materials and methods

CT images were obtained from COPDGene. 50 subjects were randomly selected per GOLD stage (0 to 4), GOLD-unclassified, and never-smoker groups and allocated to either "Healthy," "Mild," or "Moderate/severe" groups. 26/350 (7.4%) subjects had missing images and were excluded. Supported by computer-aided detection, a trained researcher prelocated non-calcified opacities larger than 3 mm in diameter. Included lung opacitie

SUBMITTER: Schreuder A 

PROVIDER: S-EPMC7337033 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature