The Impact of Recessive Deleterious Variation on Signals of Adaptive Introgression in Human Populations.

ABSTRACT: Admixture with archaic hominins has altered the landscape of genomic variation in modern human populations. Several gene regions have been identified previously as candidates of adaptive introgression (AI) that facilitated human adaptation to specific environments. However, simulation-based studies have suggested that population genetic processes other than adaptive mutations, such as heterosis from recessive deleterious variants private to populations before admixture, can also lead to patterns in genomic data that resemble AI. The extent to which the presence of deleterious variants affect the false-positive rate and the power of current methods to detect AI has not been fully assessed. Here, we used extensive simulations under parameters relevant for human evolution to show that recessi

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7337073 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature