Genetic Signatures of Evolutionary Rescue by a Selective Sweep.

ABSTRACT: One of the most useful models in population genetics is that of a selective sweep and the consequent hitch-hiking of linked neutral alleles. While variations on this model typically assume constant population size, many instances of strong selection and rapid adaptation in nature may co-occur with complex demography. Here, we extend the hitch-hiking model to evolutionary rescue, where adaptation and demography not only co-occur but are intimately entwined. Our results show how this feedback between demography and evolution determines-and restricts-the genetic signatures of evolutionary rescue, and how these differ from the signatures of sweeps in populations of constant size. In particular, we find rescue to harden sweeps from standing variance or new mutation (but not from migration), red

SUBMITTER: Osmond MM 

PROVIDER: S-EPMC7337082 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature