Visual Psychophysics in Head-Fixed Mice.

ABSTRACT: We describe a set of protocols for doing visual psychophysical experiments in head-fixed mice. The goal of this approach was to conduct in mice the same type of precise and well-controlled tests of visual perception and decision making as is commonly done in primates. For example, these experimental protocols were the basis for our demonstration that mice are capable of visual selective attention in paradigms adapted from classic attention cueing paradigms in primates. Basic Protocol 1 describes how to construct the experimental apparatus, including the removable wheel assembly on which the mice run during the visual tasks, the lick spout used to deliver rewards and detect licks, and the behavioral box that places these components together with the visual displays. We also describe the fun

SUBMITTER: Krauzlis RJ 

PROVIDER: S-EPMC7337099 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature