A Pediatric Case of Sirolimus-Associated Pneumonitis After Kidney Transplantation.

ABSTRACT: Sirolimus is an immunosuppressive medication often used in solid organ transplantation. It has been associated with severe side effects, including pulmonary toxicity. In adult patients, a single center study found that 14% of those treated with sirolimus developed pulmonary pneumonitis; however, the incidence in the pediatric population is not known. Most reports in adult patients indicate that elevated drug concentrations and a prolonged duration of use are associated with pulmonary toxicity. We report a case of a 17-year-old male kidney transplant recipient who developed rapid-onset respiratory failure, necessitating mechanical ventilation and acute renal replacement therapy for ultrafiltration secondary to sirolimus-induced pneumonitis. He had been treated for acute rejection with corti

SUBMITTER: Kelchtermans J 

PROVIDER: S-EPMC7337132 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature