Dose-Response Relationships Between Gonadal Steroids and Bone, Body Composition, and Sexual Function in Aging Men.

ABSTRACT: Most labs set the lower limit of normal for testosterone at the 2.5th percentile of values in young or age-matched men, an approach that does not consider the physiologic changes associated with various testosterone concentrations. To characterize the dose-response relationships between gonadal steroid concentrations and measures regulated by gonadal steroids in older men. 177 men aged 60 to 80 were randomly assigned to receive goserelin acetate plus either 0 (placebo), 1.25, 2.5, 5, or 10 grams of a 1% testosterone gel daily for 16 weeks or placebos for both medications (controls). Changes in serum C-telopeptide (CTX), total body fat by dual energy X-ray absorptiometry, and self-reported sexual desire. Clear relationships between the testosterone dosage (or the resulting testosterone leve

SUBMITTER: Finkelstein JS 

PROVIDER: S-EPMC7337183 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature