Metabolic Effects of Late Dinner in Healthy Volunteers-A Randomized Crossover Clinical Trial.

ABSTRACT: Consuming calories later in the day is associated with obesity and metabolic syndrome. We hypothesized that eating a late dinner alters substrate metabolism during sleep in a manner that promotes obesity. The objective of this work is to examine the impact of late dinner on nocturnal metabolism in healthy volunteers. This is a randomized crossover trial of late dinner (LD, 22:00) vs routine dinner (RD, 18:00), with a fixed sleep period (23:00-07:00) in a laboratory setting. Participants comprised 20 healthy volunteers (10 male, 10 female), age 26.0 ± 0.6 years, body mass index 23.2 ± 0.7 kg/m2, accustomed to a bedtime between 22:00 and 01:00. An isocaloric macronutrient diet was administered on both visits. Dinner (35% daily kcal, 50% carbohydrate, 35% fat) with an oral lipid tracer ([2H31

SUBMITTER: Gu C 

PROVIDER: S-EPMC7337187 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature