Ontology highlight
ABSTRACT:
SUBMITTER: Ho N
PROVIDER: S-EPMC7337508 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
The Journal of cell biology 20200701 7
Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised, we identified pathways beyond lipid metabolism that are necessary to maintain ER integrity in yeast and in C. elegans. To systematically validate yeast mutants that disrupt ER membrane homeostasis, we identified a lipid ...[more]