The role of 3'UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization.

ABSTRACT: Multifunctional proteins often perform their different functions when localized in different subcellular compartments. However, the mechanisms leading to their localization are largely unknown. Recently, 3'UTRs were found to regulate the cellular localization of newly synthesized proteins through the formation of 3'UTR-protein complexes. Here, we investigate the formation of 3'UTR-protein complexes involving multifunctional proteins by exploiting large-scale protein-protein and protein-RNA interaction networks. Focusing on 238 human 'extreme multifunctional' (EMF) proteins, we predicted 1411 3'UTR-protein complexes involving 54% of those proteins and evaluated their role in regulating protein cellular localization and multifunctionality. We find that EMF proteins lacking localization addre

SUBMITTER: Ribeiro DM 

PROVIDER: S-EPMC7337931 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature