A clinical prediction model for cancer-associated venous thromboembolism: a development and validation study in two independent prospective cohorts.

ABSTRACT:

Background

Venous thromboembolism is a common complication of cancer, but the risk of developing venous thromboembolism varies greatly among individuals and depends on numerous factors, including type of cancer. We aimed to develop and externally validate a clinical prediction model for cancer-associated venous thromboembolism.

Methods

We used data from the prospective Vienna Cancer and Thrombosis Study (CATS) cohort (n=1423) to select prognostic variables for inclusion in the model. We then validated the model in the prospective Multinational Cohort Study to Identify Cancer Patients at High Risk of Venous Thromboembolism (MICA) cohort (n=832). We calculated c-indices to show how the predicted incidence of objectively confirmed venous thromboembolism at 6 months compared wit

SUBMITTER: Pabinger I 

PROVIDER: S-EPMC7338218 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature