The causal effect of resilience on risk for drug abuse: a Swedish national instrumental variable, co-relative and propensity-score analysis.

ABSTRACT:

Background

We sought to quantify and investigate the causal nature of the association between resilience at age 18 and future drug abuse (DA).

Method

In a national sample of Swedish men (n = 1 392 800), followed for a mean of 30.3 years, resilience was assessed during military conscription and DA defined from medical, criminal and pharmacy registers. For causal inference, we utilized three methods: (i) instrumental variable analyses with the month of birth as the instrument; (ii) co-relative analyses using the general population, cousins, siblings and monozygotic twins; and (iii) propensity scoring on a subsample (n = 48 548) with strong resilience predictors. Cox proportional hazards models were utilized to examine survival time till DA diagnosis.

Results

Low resilie

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC7338227 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature