Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms.

ABSTRACT: Hypothalamic adult neurogenesis provides the basis for renewal of neurons involved in the regulation of whole-body energy status. In addition to hormones, cytokines and growth factors, components of the diet, particularly fatty acids, have been shown to stimulate hypothalamic neurogenesis; however, the mechanisms behind this action are unknown. Here, we hypothesized that GPR40 (FFAR1), the receptor for medium and long chain unsaturated fatty acids, could mediate at least part of the neurogenic activity in the hypothalamus. We show that a GPR40 ligand increased hypothalamic cell proliferation and survival in adult mice. In postnatal generated neurospheres, acting in synergy with brain-derived neurotrophic factor (BDNF) and interleukin 6, GPR40 activation increased the expression of doubleco

SUBMITTER: Engel DF 

PROVIDER: S-EPMC7338363 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature