TIGAR/AP-1 axis accelerates the division of Lgr5^- reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation.

ABSTRACT: During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve intestinal stem cells (ISCs) and secretory progenitor cells are both reported to replenish damaged cells and contribute to crypt regeneration. However, the suppressed β-catenin/c-MYC axis within these slow-cycling cells leads to limited regenerative response to restore intestinal integrity during fatal accidental injury. Current study demonstrates that post-IR overexpression of TIGAR, a critical downstream target of c-MYC in mouse intestine, mounts a hyperplastic response in Bm

SUBMITTER: Chen F 

PROVIDER: S-EPMC7338449 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature