The Roles of Embryonic Transcription Factor BRACHYURY in Tumorigenesis and Progression.

ABSTRACT: Transcription factor brachyury, with a DNA-binding T-domain, regulates posterior mesoderm formation and notochord development through binding with highly conserved palindromic consensus sequence in a variety of organisms. The absence of brachyury expression in majority of adult normal tissues and exclusive tumor-specific expression provides the potential to be developed into a novel and promising diagnostic and therapeutic target in cancer. As a sensitive and specific marker in the diagnosis of chordoma, brachyury protein has been verified to involve in the process of carcinogenesis and progression of chordoma and several epithelial carcinomas in various studies, but the mechanism by which brachyury promotes tumor cells migrate, invade and metastasis still remains less clear. To this end,

SUBMITTER: Chen M 

PROVIDER: S-EPMC7338565 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature