Modulating Alginate Hydrogels for Improved Biological Performance as Cellular 3D Microenvironments.

ABSTRACT: The rational choice and design of biomaterials for biomedical applications is crucial for successful in vitro and in vivo strategies, ultimately dictating their performance and potential clinical applications. Alginate, a marine-derived polysaccharide obtained from seaweeds, is one of the most widely used polymers in the biomedical field, particularly to build three dimensional (3D) systems for in vitro culture and in vivo delivery of cells. Despite their biocompatibility, alginate hydrogels often require modifications to improve their biological activity, namely via inclusion of mammalian cell-interactive domains and fine-tuning of mechanical properties. These modifications enable the addition of new features for greater versatility and control over alginate-ba

SUBMITTER: Neves MI 

PROVIDER: S-EPMC7338591 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature