Sympathetic nervous system activity and reactivity in women with gestational diabetes mellitus.

ABSTRACT:

Introduction

Gestational diabetes mellitus (GDM) is associated with vascular dysfunction. Sympathetic nervous system activity (SNA) is an important regulator of vascular function, and is influenced by glucose and insulin. The association between GDM and SNA (re)activity is unknown. We hypothesize that women with GDM would have increased SNA during baseline and during stress.

Methods

Eighteen women with GDM and 18 normoglycemic pregnant women (controls) were recruited. Muscle SNA (MSNA; peroneal microneurography) was assessed at rest, during a cold pressor test (CPT) and during peripheral chemoreflex deactivation (hyperoxia). Spontaneous sympathetic baroreflex gain was quantified versus diastolic pressure at rest and during hyperoxia.

Results

Age, gestational age (thir

SUBMITTER: Reyes LM 

PROVIDER: S-EPMC7338594 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature