A systematic review and network meta-analysis of current and investigational treatments for active ankylosing spondylitis.

ABSTRACT:

Objective

To compare the relative efficacy of current and investigational biologic and oral small molecule (OSM) treatments for active ankylosing spondylitis (AS).

Methods

A systematic literature review was conducted to identify all phase 2/3 randomized trials of interest in patients with AS. Outcomes assessed were ≥ 20% improvement in the Assessment of Spondyloarthritis International Society Criteria (ASAS20) and change from baseline in Bath Ankylosing Spondylitis Functional Index (BASFI) and C-reactive protein (CRP) at weeks 12-16. Bayesian network meta-analyses were conducted for outcomes using a random effects model. Baseline-risk adjustment was also conducted to account for differences in placebo response across studies. Surface Under the Cumulative Ranking curve (SUCRA

SUBMITTER: Deodhar A 

PROVIDER: S-EPMC7338808 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature