A Rational Approach to Understanding and Evaluating Responsive Neurostimulation.

ABSTRACT: Closed-loop brain stimulation is increasingly used in level 4 epilepsy centers without an understanding of how the device behaves on a daily basis. This lack of insight is a barrier to improving closed-loop therapy and ultimately understanding why some patients never achieve seizure reduction. We aimed to quantify the accuracy of closed-loop seizure detection and stimulation on the RNS device through extrapolating information derived from manually reviewed ECoG recordings and comprehensive device logging information. RNS System event logging data were obtained, reviewed, and analyzed using a custom-built software package. A weighted-means methodology was developed to adjust for bias and incompleteness in event logs and evaluated using Bland-Altman plots and Wilcoxon signed-rank tests to co

SUBMITTER: Sisterson ND 

PROVIDER: S-EPMC7338816 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature