Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults.

ABSTRACT:

Purpose

The abnormal deposition of tau begins before the onset of clinical symptoms and seems to target specific brain networks. The aim of this study is to identify the spatial patterns of tau deposition in cognitively normal older adults and assess whether they are related to amyloid-β (Aβ), APOE, sex, and longitudinal cognitive decline.

Methods

We included 114 older adults with cross-sectional flortaucipir (FTP) and Pittsburgh Compound-B PET in addition to longitudinal cognitive testing. A voxel-wise independent component analysis was applied to FTP images to identify the spatial patterns of tau deposition. We then assessed whether tau within these patterns differed by Aβ status, APOE genotype, and sex. Linear mixed effects models were built to test whether tau in each co

SUBMITTER: Pereira JB 

PROVIDER: S-EPMC7338820 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature