Initial experience with [¹⁸F]DPA-714 TSPO-PET to image inflammation in primary angiitis of the central nervous system.

ABSTRACT:

Purpose

Primary angiitis of the central nervous system (PACNS) is a heterogeneous, rare, and poorly understood inflammatory disease. We aimed at non-invasive imaging of activated microglia/macrophages in patients with PACNS by PET-MRI targeting the translocator protein (TSPO) with [¹⁸F]DPA-714 to potentially assist differential diagnosis, therapy monitoring, and biopsy planning.

Methods

In total, nine patients with ischemic stroke and diagnosed or suspected PACNS underwent [¹⁸F]DPA-714-PET-MRI. Dynamic PET scanning was performed for 60 min after injection of 233 ± 19 MBq [¹⁸F]DPA-714, and MRI was simultaneously acquired.

Results

In two PACNS patients, [¹⁸F]DPA-714 uptake patterns exceeded MRI correlates of infarction, wherea

SUBMITTER: Backhaus P 

PROVIDER: S-EPMC7338821 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature