Discordance Between Serology and Histology for Celiac Disease in a Cohort with Coexisting Liver Disorders.

ABSTRACT:

Background

The liver and celiac disease (CeD) share a complex relationship. While in some patients, isolated hypertransaminasemia is the only manifestation of CeD, liver diseases (LD) may also be associated with the presence of isolated tissue transglutaminase antibodies IgA (tTG IgA) without histologic evidence of CeD.

Aims

To examine the yield of tTG IgA testing (a) in the workup for chronic liver disease (CLD) or cytolysis and (b) to identify biopsy-confirmed CeD (BxCeD) among patients with concomitant LD.

Methods

Retrospective study including two cohorts. Cohort 1 represented 444 consecutive individuals without known CeD for which liver specialists requested tTG IgA. Incidence of positive tTG and BxCeD was evaluated. Cohort 2 included 212 consecutive individuals w

SUBMITTER: Cvetkovic L 

PROVIDER: S-EPMC7338843 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature