Sex, Gender, and Sex Hormones in Pulmonary Hypertension and Right Ventricular Failure.

ABSTRACT: Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized by elevated pulmonary artery pressure and pulmonary vascular remodeling and that frequently lead to right ventricular (RV) failure and death. Several types of PH exhibit sexually dimorphic features in disease penetrance, presentation, and progression. Most sexually dimorphic features in PH have been described in pulmonary arterial hypertension (PAH), a devastating and progressive pulmonary vasculopathy with a 3-year survival rate <60%. While patient registries show that women are more susceptible to development of PAH, female PAH patients display better RV function and increased survival compared to their male counterparts, a phenomenon referred to as the "estrogen paradox" or "estrogen puzzle" of PAH. Re

SUBMITTER: Hester J 

PROVIDER: S-EPMC7338988 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature