Incidence of androgen receptor and androgen receptor variant 7 coexpression in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PRCA) is an androgen-driven disease, where androgens act through the androgen receptor (AR) to induce proliferation and survival of tumor cells. Recently, AR splice variant 7 (ARv7) has been implicated in advanced stages of PRCA and clinical recurrence. With the widespread use of AR-targeted therapies, there has been a rising interest in the expression of full-length AR and ARv7 in PRCA progression and how these receptors, both independently and together, contribute to adverse clinicopathologic outcomes.

Methods

Despite a multitude of studies measuring the expression levels of AR and ARv7 in PRCA progression, the results have been inconsistent and sometimes contradictory due to technical and analytical discrepancies. To circumvent these inconsiste

SUBMITTER: Vellky JE 

PROVIDER: S-EPMC7339117 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature