Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.

ABSTRACT:

Objective

Fasting regimens can promote health, mitigate chronic immunological disorders, and improve age-related pathophysiological parameters in animals and humans. Several ongoing clinical trials are using fasting as a potential therapy for various conditions. Fasting alters metabolism by acting as a reset for energy homeostasis, but the molecular mechanisms underlying the beneficial effects of short-term fasting (STF) are not well understood, particularly at the systems or multiorgan level.

Methods

We performed RNA-sequencing in nine organs from mice fed ad libitum (0 h) or subjected to fasting five times (2-22 h). We applied a combination of multivariate analysis, differential expression analysis, gene ontology, and network analysis for an in-depth understanding of the m

SUBMITTER: Huang SSY 

PROVIDER: S-EPMC7339127 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature