Application of mesenchymal stem cell exosomes and their drug-loading systems in acute liver failure.

ABSTRACT: Stem cell exosomes are nanoscale membrane vesicles released from stem cells of various origins that can regulate signal transduction pathways between liver cells, and their functions in intercellular communication have been recognized. Due to their natural substance transport properties and excellent biocompatibility, exosomes can also be used as drug carriers to release a variety of substances, which has great prospects in the treatment of critical and incurable diseases. Different types of stem cell exosomes have been used to study liver diseases. Due to current difficulties in the treatment of acute liver failure (ALF), this review will outline the potential of stem cell exosomes for ALF treatment. Specifically, we reviewed the pathogenesis of acute liver failure and the latest progress

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7339207 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature