Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization.

ABSTRACT: BACKGROUND:Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarization. Sleep disorders are well known risk factors for migraine chronification, and changes in wake-sleep pattern such as sleep deprivation are common migraine triggers. The underlying mechanisms are unknown. As a step towards developing an animal model to study this, we test whether sleep deprivation, a modifiable migraine trigger, enhances CSD susceptibility in rodent models. METHODS:Acute sleep deprivation was achieved using the "gentle handling method", chosen to minimize stress and avoid confounding bias. Sleep deprivation was started with onset of light (diurnal lighting

SUBMITTER: Negro A 

PROVIDER: S-EPMC7339460 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature