A systems biology-driven approach to construct a comprehensive protein interaction network of influenza A virus with its host.

ABSTRACT:

Background

Influenza A virus (IAV) infection is a serious public health problem not only in South East Asia but also in European and African countries. Scientists are using network biology to dig deep into the essential host factors responsible for regulation of virus infections. Researchers can explore the virus invasion into the host cells by studying the virus-host relationship based on their protein-protein interaction network.

Methods

In this study, we present a comprehensive IAV-host protein-protein interaction network that is obtained based on the literature-curated protein interaction datasets and some important interaction databases. The network is constructed in Cytoscape and analyzed with its plugins including CytoHubba, CytoCluster, MCODE, ClusterViz and ClusterO

SUBMITTER: Farooq QUA 

PROVIDER: S-EPMC7339526 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature